Insights into the Wnt Signaling Pathway Evolution

Animals’ Wnt signaling pathways are highly preserved signal transduction pathways, which play a crucial role in embryogenesis and adult tissue homeostasis. This chapter reviews the three major focusing on some critical proteins Wnt/β-catenin path terms of their evolution act as gateway between extracellular, cytoplasmic, nuclear components to transmit pathways. The Frizzled (FZD) family G-protein-coupled receptors activates by binding ligands. LRP5/6, members low-density lipoprotein (LDLR), associate with FZD receptor ligands co-receptors initiate pathway. pathway is regulated antagonists such Dickkopf secreted Frizzled-related protein (SFRP) families.